Julius Friedemann Werner, M.Sc.

2022 [ to top ]

• Ferrero, V., Werner, J., Aglietta, M., Cerello, P., Fiorina, E., Gorgi, A., Vignati, A., Rafecas, M. and Pennazio, F.: The MERLINO project:characterization of LaBr3:Ce detectors for stopping power monitoring in proton therapy, Journal of Instrumentation, 17(11), C11013, 2022, DOI: 10.1088/1748-0221/17/11/C11013.
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  @article{Ferrero_2022, abstract = {The MERLINO project is developing a multi-detector setup with the goal of evaluating the beam stopping power from Prompt-Gamma-Timing measurements in proton therapy. The detectors are based on the cerium-doped lanthanum bromide crystal, LaBr3:Ce, coupled to photo-multiplier tubes. The system characterization is ongoing and the first calibration measurements with two detectors showed 124 ps σ and σ E/E = 3% for the timing and energy resolution, respectively. The measured experimental parameters were then used to carry out a preliminary estimation of the stopping power. Results from the simulation of a 189 MeV proton beam impinging on an homogeneous phantom are presented for the optimisation of the MERLINO detector setup.}, author = {Ferrero, V. and Werner, J. and Aglietta, M. and Cerello, P. and Fiorina, E. and Gorgi, A. and Vignati, A. and Rafecas, M. and Pennazio, F.}, journal = {Journal of Instrumentation}, keywords = {NucI NucIRangeVerification RafecasMagdalena WernerJulius imt}, month = {nov}, number = 11, pages = {C11013}, publisher = {IOP Publishing}, title = {The MERLINO project:characterization of LaBr3:Ce detectors for stopping power monitoring in proton therapy}, volume = 17, year = 2022 }
• Ferrero, V., Werner, J., Cerello, P., Fiorina, E., Vignati, A., Pennazio, F. and Rafecas, M.: Estimating the stopping power distribution during proton therapy: A proof of concept, Frontiers in Physics, 2022, DOI: 10.3389/fphy.2022.971767.
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  @article{ferrero2022estimating, abstract = {Objective. We introduce a new treatment verification technique to estimate the primary particle's stopping power from prompt gamma timing measurements in proton therapy. Approach. The starting point is the Spatio-temporal Emission Recostruction technique, which provides the time-depth distribution of the emitted prompt photons with a multiple Prompt-Gamma Timing detector setup based on Lanthanum Bromide crystals. A dedicated formalism based on an analytical approximation of the stopping power is developed to obtain the desired information. Its performance is evaluated in a proof of concept configuration via Monte Carlo simulations of monochromatic proton beams impinging on a homogeneous PMMA phantom. Main Results. Results indicate stopping power estimations as good as 3.8% with respect to NIST values, and range estimations within 0.3 cm (standard deviation), when considering 250 ps FWHM timing resolution. Significance. The current study shows, for the first time, the feasibility of evaluating the stopping power of primary beams with a technique that can be performed in-vivo, opening up new possibilities in the field of treatment verification and therapy optimization.}, author = {Ferrero, Veronica and Werner, Julius and Cerello, Piergiorgio and Fiorina, Elisa and Vignati, Anna and Pennazio, Francesco and Rafecas, Magdalena}, editor = {Vasquez Osorio, Eliana Maria}, journal = {Frontiers in Physics}, keywords = {NucI NucIRangeVerification RafecasMagdalena WernerJulius imt myown}, month = {sep}, publisher = {Frontiers}, title = {Estimating the stopping power distribution during proton therapy: A proof of concept}, type = {article}, year = 2022 }
• Pennazio, F., Ferrero, V., D'Onghia, G., Garbolino, S., Fiorina, E., Villarreal, O. A. M., Milian, F. M., Monaco, V., Monti, V., Patera, A., Werner, J., Wheadon, R. and Rafecas, M.: Proton therapy monitoring: spatiotemporal emission reconstruction with prompt gamma timing and implementation with PET detectors, Physics in Medicine & Biology, 67(6), 065005, 2022, DOI: 10.1088/1361-6560/ac5765.
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  @article{Pennazio_2022, author = {Pennazio, Francesco and Ferrero, Veronica and D'Onghia, Grazia and Garbolino, Sara and Fiorina, Elisa and Villarreal, Oscar Ariel Marti and Milian, Felix Mas and Monaco, Vincenzo and Monti, Valeria and Patera, Alessandra and Werner, Julius and Wheadon, Richard and Rafecas, Magdalena}, journal = {Physics in Medicine & Biology}, keywords = {NucIRangeVerification RafecasMagdalena WernerJulius imt myown}, month = {mar}, number = 6, pages = {065005}, publisher = {{IOP} Publishing}, title = {Proton therapy monitoring: spatiotemporal emission reconstruction with prompt gamma timing and implementation with {PET} detectors}, volume = 67, year = 2022 }