Photon Cross-Correlation Spectroscopy of Nanoparticles

The hydrodynamic diameter and the surface characteristics of the SPIONs are of great importance in terms of clearance, cell response, toxicity, and biocompatibility, especially for medical or biological applications. In general, the spleen and liver as a result of mechanical filtration remove SPIONs approximately of 200 nm in diameter. To characterize the hydrodynamic diameter of the SPIONs we use dynamic light scattering. Dynamic light scattering, more precisely Photon Cross-correlation Spectroscopy (PCCS), is a technique which can be used to determine the size distribution profile of small particles in suspension or polymers in solution. Photon Cross-correlation Spectroscopy is also a technique which allows the simultaneous measurement of precise particle size and stability in the range of about 1 nm to some µm in opaque suspensions and emulsions.

It is important that the particles are stable over a long time without forming agglomerates. Therefore the stability of the SPIONs has to be analysed in different media at different pH values varying from 4.6 to 10.0 at room temperature and e.g. at 37°C. We use different media like PBS and characterized over 6 weeks the hydrodynamic diameter and the stability of the particles.

Photon cross-correlation spectroscopy


2019[ to top ]
  • Rehberg, I., Richter, R., Hartung, S., Lucht, N., Hankiewicz, B. and Friedrich, T.: Measuring magnetic moments of polydisperse ferrofluids utilizing the inverse Langevin function, Physical Review B, 100(13), 134425, 2019, DOI: 10.1103/PhysRevB.100.134425.
  • Malhotra, A., von Gladiss, A., Behrends, A., Friedrich, T., Neumann, A., Buzug, T. M. and Lüdtke-Buzug, K.: Tracking the Growth of Superparamagnetic Nanoparticles with an In-Situ Magnetic Particle Spectrometer (INSPECT), Scientific Reports, 9(10538), 2019, DOI:
2018[ to top ]
  • Debbeler, C., von Gladiss, A., Friedrich, T., Buzug, T. M. and Lüdtke-Buzug, K.: New MPI Tracer Material - A Resolution Study, 33–34, 2018.
2016[ to top ]
  • Malhotra, A., Spieß, F., Stegelmeier, C., Debbeler, C. and Lüdtke-Buzug, K.: Effect of key parameters on synthesis of superparamagnetic nanoparticles (SPIONs), Current Directions in Biomedical Engineering, 2(1), 529–532, 2016, DOI: 10.1515/cdbme-2016-0117.
2015[ to top ]
  • Debbeler, C., Boy, A. and Lüdtke-Buzug, K.: Synthesis of Superparamagnetic Iron Oxide Nanoparticles under Ultrasound Control, Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 60(s1), s-27, 2015, DOI: 10.1515/bmt-2015-5000.
  • Welzel, T., Debbeler, C., Graeser, M., Kaufmann, S., Kusche, R. and Lüdtke-Buzug, K.: Analyzing Superparamagnetic Iron Oxide Nanoparticles (SPIONs) using Electrical Impedance Spectroscopy, 2015, DOI: 10.1109/IWMPI.2015.7107062.
  • Kläser, K., Graeser, M., Steinhagen, D. and Lüdtke-Buzug, K.: Construction of a device for magnetic separation of superparamagnetic iron oxide nanoparticles, Current Directions in Biomedical Engineering, 1(1), 306–309, 2015, DOI: 10.1515/cdbme-2015-0076.
  • Duda, K. and Lüdtke-Buzug, K.: Stability analysis of ferrofluids, Current Directions in Biomedical Engineering, 1(1), 10–13, 2015, DOI: 10.1515/cdbme-2015-0003.
  • Kuschnerus, I. and Lüdtke-Buzug, K.: Development and characterization of superparamagnetic coatings, Current Directions in Biomedical Engineering, 1(1), 1–4, 2015, DOI: 10.1515/cdbme-2015-0001.
  • Panagiotopoulos, N., Duschka, R. L., Ahlborg, M., Bringout, G., Debbeler, C., Graeser, M., Kaethner, C., Lüdtke-Buzug, K., Medimagh, H., Stelzner, J., Buzug, T. M., Barkhausen, J., Vogt, F. and Haegele, J.: Magnetic particle imaging: current developments and future directions, International Journal of Nanomedicine, 10, 3097–3114, 2015, DOI: 10.2147/ijn.s70488.
  • Bienzeisler, J., Lüdtke-Buzug, K. and Schemberg, J.: Magnetic Flow Field Separation of Superparamagnetic Dextran Coated Iron Oxide Nanoparticles, 2015, DOI: 10.1109/IWMPI.2015.7107063.
2014[ to top ]
  • Lüdtke-Buzug, K. and Debbeler, C.: Superparamagnetic Coatings for Magnetic Particle Imaging, 2014, DOI: 10.1515/bmt-2014-5009.
  • Lüdtke-Buzug, K. and Debbeler, C.: Development of Superparamagnetic Surface Coatings, 158, 2014.
  • Lindemann, A., Lüdtke-Buzug, K., Fraederich, B. M., Gräfe, K., Pries, R. and Wollenberg, B.: Biological impact of superparamagnetic iron oxide nanoparticles for magnetic particle imaging of head and neck cancer cells, International Journal of Nanomedicine, 9, 5025–5040, 2014, DOI: 10.2147/ijn.s63873.
  • Baumann, K., Stegmann-Frehse, J., Rody, A., Gräfe, K., Lüdtke-Buzug, K., Buzug, T. and Finas, D.: Weiterentwicklung des SNLB-Konzept unter Verwendung von SPIOs beim Mammakarzinom - Prozessierung der Nanopartikel im Organismus, Senologie, 11-A13, 2014, DOI: 10.1055/s-0034-1375372.
  • Lüdtke-Buzug, K. and Debbeler, C.: Development of SPION-Coatings for Visualization of Surgical Instruments in Magnetic Particle Imaging, 2014.
2013[ to top ]
  • Henrik, R., Marlitt, E., M., B. T. and Kerstin, L.-B.: Simulation of the magnetization dynamics of diluted ferrofluids in medical applications, Biomedizinische Technik / Biomedical Engineering, 58(6), 601–609, 2013, DOI: 10.1515/bmt-2013-0034.
  • Lüdtke-Buzug, K.: Magnetische Nanopartikel - Tracer für Magnetic Particle Imaging, 15, 2013.
  • Krieger, J., Köhler, K., Graeser, M. and Lüdtke-Buzug, K.: Construction of a Spectrometer to Measure the Cotton-Mouton Effect of Superparamagnetic Iron Oxide Nanoparticles, 2013, DOI: 10.1515/bmt-2013-4102.
  • Debbeler, C., Müller, J. and Lüdtke-Buzug, K.: Micro CT-based validation of iron concentration for MPI tracers, 2013, DOI: 10.1109/IWMPI.2013.6528337.
  • L, A. and K, L.-B.: Investigation of Different Tissue Samples with ΜCT and MPS for Determination of Iron Oxide Concentration in Tracers for MPI, 2013, DOI: 10.1515/bmt-2013-4100.
  • Oberle, A. and Lüdtke-Buzug, K.: Stability Analysis Of Superparamagnetic Iron Oxide Nanoparticles (Spions) At 37 °C, 2013, DOI: 10.1515/bmt-2013-4099.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Rody, A., Lüdtke-Buzug, K. and Buzug, T.: Superparamagnetic nanoparticles in lymphatic tissue - Detection and distribution in a breast cancer model for magnetic particle imaging, 2013, DOI: 10.1109/IWMPI.2013.6528390.
2012[ to top ]
  • Lüdtke-Buzug, K.: Magnetische Nanopartikel - Von der Synthese zur klinischen Anwendung, Chemie in unserer Zeit, 46(1), 32–39, 2012, DOI: 10.1002/ciuz.201200558.
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Buzug, T. and Lüdtke-Buzug, K.: Detection and distribution of superparamagnetic nanoparticles in lymphatic tissue in a breast cancer model for magnetic particle imaging, 81–83, 2012, DOI: 10.1515/bmt-2012-4158.