IMAGINE (Interventions guided by MAGnetic Imaging and Nanoparticle coated Equipment)

Magnetic Particle Imaging (MPI) allows to image the spatial distribution of superparamagnetic iron oxide nanoparticles (SPION). Since MPI combines a high sensitivity with good spatial and temporal resolution it is a promising technique for cardiovascular interventions. An essential aspect for a clinical use is the combination of MPI and Magnetic Resonance Tomography (MRI), since MRI provides important information about the anatomy of the patient that is missing in MPI.

Within this project the visualization of SPION-coated instruments for the use in MPI as well as MRI is investigated. The main focus is a real-time reconstruction and visualization of MPI data. Further, the safety of the instruments will be investigated with respect to heating.

Color MPI visualization of an SPION coated catheter (red) and a SPION filled lumen (white). Images taken from Haegele et al. DOI 10.1088/0031-9155/61/16/N415


  • Federal Ministry of Education and Research under grant number BMBF 01DL17010A


  • Department of Radiology and Nuclear Medicine, University of Lübeck
  • University of Bilkent
  • Aselsan
  • Nano4Imaging


2022[ to top ]
  • Wegner, F., Lüdtke-Buzug, K., Cremers, S., Friedrich, T., Sieren, M. M., Haegele, J., Koch, M. A., Saritas, E. U., Borm, P., Buzug, T. M., Barkhausen, J. and Ahlborg, M.: Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging---A Proof-of-Concept Study, Nanomaterials, 12(10), 1758, 2022, DOI: 10.3390/nano12101758.
  • Wegner, F., Cremers, S., Lüdtke-Buzug, K., Koch, M. A., Friedrich, T., Grzyska, U., Sieren, M. M., Haegele, J., Borm, P., Buzug, T. M., Barkhausen, J. and Ahlborg, M.: Instrument markers for magnetic particle and magnetic resonance imaging, 2022.
2021[ to top ]
  • Wegner, F., von Gladiss, A., Haegele, J., Grzyska, U., Sieren, M. M., Stahlberg, E., Oechtering, T. H., Lüdtke-Buzug, K., Barkhausen, J., Buzug, T. M. and Friedrich, T.: Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents, International Journal of Nanomedicine, 16, 213–221, 2021, DOI: 10.2147/IJN.S284694.
2020[ to top ]
  • Wegner, F., Friedrich, T., von Gladiss, A., Grzyska, U., Sieren, M. M., Lüdtke-Buzug, K., Frydrychowicz, A., Buzug, T. M., Barkhausen, J. and Haegele, J.: Magnetic Particle Imaging: Artifact-Free Metallic Stent Lumen Imaging in a Phantom Study, CardioVascular and Interventional Radiology, 43(2), 331–338, 2020, DOI: 10.1007/s00270-019-02347-x.
2018[ to top ]
  • Wegner, F., Friedrich, T., Panagiotopoulos, N., Valmaa, S., Goltz, J. P., Vogt, F. M., Koch, M. A., Buzug, T. M., Barkhausen, J. and Haegele, J.: First heating measurements of endovascular stents in magnetic particle imaging, Physics in Medicine and Biology, 63(4), 045005, 2018, DOI: 10.1088%2F1361-6560%2Faaa79c.