MAPIT (Magnetic Particle Imaging Technology)

MAPIT – “Magnetic Particle Imaging Technology” – is a large-scale joint research project dealing with the exploration of Magnetic Particle Imaging. Partners from industry and science collaborate concerning basic research, hardware development and optimization, aiming at preclinical and clinical applications in functional, molecular and interventional imaging, especially cardiac assessment and the image guidance of cardiovascular interventions. One major aspect in the project is the characterization and improvement of superparamagnetic iron oxide nanoparticles, which are used as tracer material in the imaging process. The other focus lies on the instrumentation: three different MPI scanner setups are being developed and implemented, including a hybrid MPI/MRI scanner.

In cooperation with the clinical partners from the Department of Radiology and Nuclear Medicine of the University Hospital of Schleswig-Holstein, Campus Lübeck, the Institute of Medical Engineering is developing an MPI scanner setup, which shall be used for the image guidance of cardiovascular interventions in animals. In addition to coil and scanner design as well as signal generation and processing, research is conducted in the fields of efficient image acquisition and reconstruction, image quality and image artifacts. Further studies cover the visualization of interventional instruments and safety aspects, particularly heating of utilized devices.

Left: electromagnetic coil for an MPI scanner, right: simulation of an MPI scanner for a mini pig.

Grants

  • Federal Ministry of Education and Research under grant number BMBF 13N11090
  • State Schleswig-Holstein (Programme for the Future – Economy) under grant number 122-10-004

Cooperations

  • Department of Radiology and Nuclear Medicine, University Hospital of Schleswig-Holstein, Campus Luebeck
  • Philips Medical Systems DMC GmbH
  • Bruker BioSpin GmbH, Bruker BioSpin MRI GmbH
  • Bayer Healthcare – Bayer Pharma AG
  • Charité – Universitätsmedizin Berlin
  • Physikalisch-Technische Bundesanstalt (PTB)

Publications

2022[ to top ]
  • Stelzner, J., Bakenecker, A., Behrends, A., Bringout, G., Chen, X., von Gladiss, A., Gräfe, K., Schumacher, J. and Buzug, T.: Implementation and imaging with a versatile 180 mm magnetic particle imaging field generator, Journal of Magnetism and Magnetic Materials, 169509, 2022, DOI: 10.1016/j.jmmm.2022.169509.
2020[ to top ]
  • Stelzner, J., Gräfe, K. and Buzug, T. M.: First images obtained with a rabbit-sized Magnetic Particle Imaging scanner, International Journal on Magnetic Particle Imaging, Vol 6 No 2 Suppl. 1 (2020), 2020, DOI: https://doi.org/10.18416/IJMPI.2020.2009033.
2018[ to top ]
  • Stelzner, J., Beuke, J., Wei, H. and Buzug, T. M.: A Customized Highly Linear Power Resistor For Distortion Measurements in a Magnetic Particle Imaging Signal Chain, 2018.
  • Stelzner, J., Weber, M. and Buzug, T. M.: A Receive Coil Topology Based on Oppositely Tilted Solenoids for a Predefined Drive Field, 81–82, 2018.
2017[ to top ]
  • Bakenecker, A., Friedrich, T., von Gladiss, A., Graeser, M., Stelzner, J. and Buzug, T. M.: Experimental Validation of the Selection Field of a Rabbit Sized FFL Scanner, 41, 2017.
  • Bakenecker, A., Friedrich, T., von Gladiss, A., Graeser, M., Stelzner, J. and Buzug, T. M.: Experimental Validation of the Selection Field of a Rabbit-Sized FFL Scanner, International Journal on Magnetic Particle Imaging, 3(1), 2017, DOI: 10.18416/IJMPI.2017.1703013.
  • Stelzner, J., Graeser, M., Bakenecker, A., von Gladiss, A., Bringout, G. and Buzug, T. M.: Measurements Inside a Rabbit Sized FFL-MPI Device Using a Gradiometric Receive Coil, International Journal on Magnetic Particle Imaging, 3(1), 2017, DOI: 10.18416/IJMPI.2017.1703012.
2016[ to top ]
  • Bringout, G., Löfberg, J., Ulloa, P., Koch, M. A. and Buzug, T. M.: Designing coils to minimize the maximal induced electrical field amplitude in a patient, 32, 2016.
  • Medimagh, H. and Buzug, T. M.: Predicting 2D MPI imaging performance using a conventionally acquired or a hybrid 2D system function, 2016.
  • Stelzner, J., Bringout, G., von Gladiss, A., Medimagh, H., Ahlborg, M., Sattel, T. F. and Buzug, T. M.: First Spectrum Measurements with a Rabbit-Sized FFL-Scanner, 138, 2016.
2015[ to top ]
  • Omer, O., Medimagh, H. and Buzug, T.: High resolution magnetic particle imaging with low density trajectory, 2015, DOI: 10.1109/IWMPI.2015.7106995.
  • Bringout, G., Gräfe, K. and Buzug, T. M.: Performance of Shielded Electromagnet-Evaluation Under Low-Frequency Excitation, IEEE Transactions on Magnetics, 51(2), 1–4, 2015, DOI: 10.1109/TMAG.2014.2329396.
  • Panagiotopoulos, N., Duschka, R. L., Ahlborg, M., Bringout, G., Debbeler, C., Graeser, M., Kaethner, C., Lüdtke-Buzug, K., Medimagh, H., Stelzner, J., Buzug, T. M., Barkhausen, J., Vogt, F. and Haegele, J.: Magnetic particle imaging: current developments and future directions, International Journal of Nanomedicine, 10, 3097–3114, 2015, DOI: 10.2147/ijn.s70488.
  • Medimagh, H., Weissert, P., Bringout, G., Bente, K., Weber, M., Gräfe, K., Cordes, A. and Buzug, T.: Artifacts in field free line magnetic particle imaging in the presence of inhomogeneous and nonlinear magnetic fields, Current Directions in Biomedical Engineering, 1(1), 245–248, 2015, DOI: 10.1515/cdbme-2015-0061.
  • Graeser, M., Bente, K., Neumann, A. and Buzug, T. M.: Trajectory Dependent Particle Response for Anisotropic Mono Domain Particles in Magnetic Particle Imaging, Journal of Physics D: Applied Physics, 49(4), 2015, DOI: 10.1088/0022-3727/49/4/045007.
  • Medimagh, H., Weissert, P., Bringout, G., Bente, K., Weber, M., Gräfe, K., Cordes, A. and Buzug, T. M.: Artifacts in Field Free Line Magnetic Particle Imaging in the Presence of Inhomogeneous and Nonlinear Magnetic Fields, 2015.
  • Stelzner, J., Bringout, G., Graeser, M. and Buzug, T. M.: Toriodal Variometer for a Magnetic Particle Imaging Device, 92, 2015, DOI: 10.1109/IWMPI.2015.7107074.
  • Bringout, G., Stelzner, J., Ahlborg, M., Behrends, A., Bente, K., Debbeler, C., von Gladiß, A., Gräfe K., Graeser, M., Kaethner, C., Kaufmann, S., Lüdtke-Buzug K., Medimagh, H., Tenner, W., Weber, M. and Buzug, T. M.: Concept of a Rabbit-Sized FFL-Scanner, 49, 2015.
  • Medimagh, H., Weissert, P., Bringout, G., Bente, K., Weber, M., Gräfe, K., Cordes, A. and Buzug, T.: Artifacts in field free line magnetic particle imaging, 2015, DOI: 10.1109/IWMPI.2015.7107043.
  • Graeser, M., Ahlborg, M., Behrends, A., Bente, K., Bringout, G., Debbeler, C., v. Gladiß, A., Gräfe, K., Kaethner, C., Kaufmann, S., Lüdtke-Buzug, K., Medimagh, H., Stelzner, J., Weber, M. and Buzug, T. M.: A Device for Measureing the Trajectorey Dependent Magnetic Particle Performance for MPI, 2015, DOI: 10.1109/IWMPI.2015.7107078.
2014[ to top ]
  • Bringout, G. and Buzug, T. M.: A robust and compact representation for magnetic fields in magnetic particle imaging, 646–650, 2014, DOI: 10.1515/bmt-2014-5009.
  • Bringout, G., Ahlborg, M., Graeser, M., Kaethner, C., Stelzner, J., Tenner, W., Wojtczyk, H. and Buzug, T. M.: Shielded drive coils for a rabbit sized FFL scanner, 98, 2014.
  • Stelzner, J., Graeser, M. and Buzug, T. M.: Design and Construction of a Toroidal Filter Coil for a Magnetic Particle Imaging Device, 679–682, 2014, DOI: 10.1515/bmt-2014-4280.
  • Bringout, G. and Buzug, T.: Coil Design for Magnetic Particle Imaging: Application for a Preclinical Scanner, IEEE Transactions on Magnetics, 51(2), 5100808, 2014, DOI: 10.1109/TMAG.2014.2344917.
  • Omer, O. A., Wojtczyk, H. and Buzug, T. M.: Simultaneous Reconstruction and Resolution Enhancement for Magnetic Particle Imaging, 28–29, 2014.
  • v. Gladiß, A., Ahlborg, M., Knopp, T. and Buzug, T. M.: Compressed Sensing and Sparse Reconstruction in MPI, 19–20, 2014.
  • Duschka, R., Wojtczyk, H., Panagiotopoulos, N., Haegele, J., Bringout, G., Buzug, T., Barkhausen, J. and Vogt, F.: Safety Measurements for Heating of Instruments for Cardiovascular Interventions in Magnetic Particle Imaging ({MPI}) - First Experiences, Journal of Healthcare Engineering, 5(1), 79–94, 2014, DOI: 10.1260/2040-2295.5.1.79.
  • Ahlborg, M., Knopp, T. and Buzug, T. M.: Comparison of X-Space and Chebychev Reconstruction in Magnetic Particle Imaging, 104–105, 2014.
  • Wojtczyk, H., Bringout, G., Tenner, W., Graeser, M., Grüttner, M., Sattel, T., Gräfe, K. and Buzug, T.: Toward the Optimization of D-Shaped Coils for the Use in an Open Magnetic Particle Imaging Scanner, IEEE Transactions on Magnetics, 50(7), 5100507, 2014, DOI: 10.1109/TMAG.2014.2303113.
  • Omer, O., Wojtczyk, H. and Buzug, T.: Simultaneous Reconstruction and Resolution Enhancement for Magnetic Particle Imaging, IEEE Transactions on Magnetics, 51(2), 6500804, 2014, DOI: 10.1109/TMAG.2014.2330553.
2013[ to top ]
  • Graeser, M., Knopp, T., Grüttner, M., Sattel, T., Bringout, G., Tenner, W., Wojtczyk, H. and Buzug, T.: Cancellation techniques for MPI, 2013, DOI: 10.1109/IWMPI.2013.6528331.
  • Bringout, G., Wojtczyk, H., Tenner, W., Graeser, M., Grüttner, M., Haegele, J., Duschka, R., Panagiotopoulos, N., Vogt, F., Barkhausen, J. and Buzug, T.: A high power driving and selection field coil for an open MPI scanner, 2013, DOI: 10.1109/IWMPI.2013.6528332.
  • Grüttner, M., Sattel, T., Bringout, G., Graeser, M., Tenner, W., Wojtczyk, H. and Buzug, T.: Truncation artifacts in Magnetic Particle Imaging, 2013, DOI: 10.1109/IWMPI.2013.6528335.
  • Wojtczyk, H., Bringout, G., Tenner, W., Graeser, M., Grüttner, M., Sattel, T., Gräfe, K., Haegele, J., Duschka, R., Panagiotopoulos, N., Vogt, F., Barkhausen, J. and Buzug, T.: Comparison of Open Scanner Designs for Interventional Magnetic Particle Imaging, 2013, DOI: 10.1515/bmt-2013-4279.
  • Tenner, W., Wojtczyk, H., Bringout, G., Graeser, M., Grüttner, M., Haegele, J., Duschka, R., Panagiotopoulos, N., Vogt, F., Barkhausen, J. and Buzug, T.: Receive coil optimization for an open magnetic particle imaging scanner, 2013, DOI: 10.1109/IWMPI.2013.6528336.
  • Timmermeyer, A., Wojtczyk, H., Tenner, W., Bringout, G., Grüttner, M., Graeser, M., Sattel, T., Halkola, A. and Buzug, T.: Super-resolution approaches for resolution enhancement in magnetic particle imaging, 2013, DOI: 10.1109/IWMPI.2013.6528360.
  • Wojtczyk, H., Timmermeyer, A., Tenner, W., Sattel, T., Bringout, G., Grüttner, M., Graeser, M. and Buzug, T.: Measure of trajectory quality in Magnetic Particle Imaging, 2013, DOI: 10.1109/IWMPI.2013.6528351.
  • Timmermeyer, A., Wojtczyk, H., Tenner, W., Bringout, G., Grüttner, M., Graeser, M., Sattel, T. F., Halkola, A. and Buzug, T. M.: Super-resolution approach in magnetic particle imaging – Evaluation of effectiveness at various noise levels, 2013.
  • Graeser, M., Knopp, T., Grüttner, M., Sattel, T. F. and Buzug, T. M.: Analog receive signal processing for magnetic particle imaging, Medical Physics, 40(4), 042303, 2013, DOI: 10.1118/1.4794482.
  • Grüttner, M., Sattel, T. F., Griese, F. and Buzug, T. M.: System matrices for field of view patches in magnetic particle imaging, 86721A, 2013, DOI: 10.1117/12.2002424.
2012[ to top ]
  • Bringout, G., Wojtczyk, H., Grüttner, M., Graeser, M., Tenner, W., Hägele, J., Vogt, F., Barkhausen, J. and Buzug, T.: Safety Aspects for a Pre-clinical Magnetic Particle Imaging Scanner, 355–359, 2012, DOI: 10.1007/978-3-642-24133-8_57.
  • Graeser, M., Knopp, T., Sattel, T., Grüttner, M. and Buzug, T.: Signal separation in magnetic particle imaging, 2483–2485, 2012, DOI: 10.1109/NSSMIC.2012.6551566.
  • Wojtczyk, H., Haegele, J., Grüttner, M., Tenner, W., Bringout, G., Graeser, M., Vogt, F., Barkhausen, J. and Buzug, T.: Visualization of Instruments in interventional Magnetic Particle Imaging (iMPI): A Simulation Study on SPIO Labelings, 167–172, 2012, DOI: 10.1007/978-3-642-24133-8_27.
  • Grüttner, M., Sattel, T., Graeser, M., Wojtczyk, H., Bringout, G., Tenner, W. and Buzug, T.: Enlarging the Field of View in Magnetic Particle Imaging – A Comparison, 249–253, 2012, DOI: 10.1007/978-3-642-24133-8_40.
  • Graeser, M., Biederer, S., Grüttner, M., Wojtczyk, H., Sattel, T., Tenner, W., Bringout, G. and Buzug, T.: Determination of System Functions for Magnetic Particle Imaging, 59–64, 2012, DOI: 10.1007/978-3-642-24133-8_10.
2011[ to top ]
  • Graeser, M., Biederer, S., Grüttner, M., Wojtczyk, H., Tenner, W., Sattel, T. F., Gleich, B., Borgert, J. and Buzug, T. M.: Determination of a 1D-MPI-System-Function using a Magnetic Particle Spectroscope, 2011.