Magnetic Particle Spectrometry

Magnetic nanoparticles are forming a promising research field in modern science. Especially in medical imaging and therapy nanoparticles may act as solution in various problems. At our institute we develop imaging systems as well as own contrast agents. A correct characterization of these particles is important for the model based reconstruction technique and for particle synthesis quality control. To characterize those particles the institute of medical engineering developed a magnetic particle spectrometer (MPS). This system is basically a zero dimensional magnetic particle imaging device. It measures the particle time response to a varying magnetic field, but resigns the gradient field that is necessary for the spatial resolution.

The correct characterization demands a high homogeneous field generator to eliminate errors due to different excitation and reception. Furthermore the sensitivity has to be maximized, to make small samples measurable and to measure low concentrations of the material in test. This leads to small coils with high homogeneous field profiles, two conflicting arguments. The institute of medical engineering is working on the optimization of those coil geometries, the optimization of the signal chain, and the development of new applications for magnetic particle spectroscopes like the hybrid reconstruction method.

Magnetic Particle Spectrometry at the Institute of Medical Engineering.

Publications

[ 2018 ] [ 2017 ] [ 2016 ] [ 2015 ] [ 2014 ] [ 2013 ] [ 2012 ] [ 2011 ] [ 2010 ] [ 2009 ]

2018 [ to top ]

  • Chen, X., Graeser, M., Behrends, A., von Gladiss, A. and Buzug, T. M.: First Measurement and SNR Results of a 3D Magnetic Particle Spectrometer, International Journal on Magnetic Particle Imaging, 4(1), 2018, DOI: 10.18416/IJMPI.2018.1810001.
     
  • Chen, X., Neumann, A. and Buzug, T. M.: Optimizing Transmit Coils for a Magnetic Particle Spectrometer, In: International Workshop on Magnetic Particle Imaging, 161, 2018.
     
  • von Gladiss, A., Graeser, M. and Buzug, T. M.: Influence of Excitation Signal Coupling on Reconstructed Images in MPI, In: International Workshop on Magnetic Particle Imaging, 47-48, 2018.
     
  • von Gladiss, A., Graeser, M. and Buzug, T. M.: Influence of Excitation Signal Coupling on Reconstructed Images in Magnetic Particle Imaging, In: Bildverarbeitung für die Medizin 2018. Informatik aktuell, Springer Vieweg, , 92-97, 2018, DOI: 10.1007/978-3-662-56537-7_36.
     

2017 [ to top ]

  • Chen, X., Graeser, M., Behrends, A., von Gladiss, A. and Buzug, T. M.: First measured result of the 3D Magnetic Particle Spectrometer, In: International Workshop on Magnetic Particle Imaging, 123, 2017.
     
  • von Gladiss, A., Graeser, M. and Buzug, T. M.: Applying Compressed Sensing on Hybrid System Matrices in Magnetic Particle Imaging, In: International Workshop on Magnetic Particle Imaging, 81, 2017.
     
  • von Gladiss, A., Graeser, M., Szwargulski, P., Knopp, T. and Buzug, T. M.: Hybrid System Calibration for Multidimensional Magnetic Particle Imaging, Physics in Medicine and Biology, 62(9), 3392-3406, 2017, DOI: 10.1088/1361-6560/aa5340.
     
  • Graeser, M., von Gladiss, A., Weber, M. and Buzug, T. M.: Two dimensional magnetic particle spectrometry, Physics in Medicine and Biology, 62(9), 3378-3391, 2017, DOI: 10.1088/1361-6560/aa5bcd.
     

2016 [ to top ]

  • Schmidt, D., Graeser, M., Gladiss, A. von, Buzug, T. M. and Steinhoff, U.: Imaging Characterization of MPI Tracers Employing Offset Measurements in a two Dimensional Magnetic Particle Spectrometer, International Journal on Magnetic Particle Imaging, 2(1), 2016.
     
  • Graeser, M., von Gladiss, A., Szwargulski, P., Ahlborg, M., Knopp, T. and Buzug, T. M.: Reconstruction of Experimental 2D MPI Data using a Hybrid System Matrix, In: International Workshop on Magnetic Particle Imaging, 130, 2016.
     
  • Chen, X., Behrends, A., Graeser, M., Neumann, A. and Buzug, T. M.: Optimizing the Coil Setup for a Three-Dimensional Magnetic Particle Spectrometer, In: International Workshop on Magnetic Particle Imaging, 59, 2016.
     
  • Schmidt, D., Graeser, M., von Gladiss, A., Buzug, T. M. and Steinhoff, U.: Imaging Characterization of MPI Tracers Employing Offset Measurements in a 2D Magnetic Particle Spectrometer, In: International Workshop on Magnetic Particle Imaging, 114, 2016.
     
  • von Gladiss, A., Graeser, M., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M. and Buzug, T. M.: The Particle Response of Blended Nanoparticles in MPI, In: International Workshop on Magnetic Particle Imaging, 115, 2016.
     

2015 [ to top ]

  • Graeser, M., Bente, K., Neumann, A. and Buzug, T. M.: Trajectory Dependent Particle Response for Anisotropic Mono Domain Particles in Magnetic Particle Imaging, Journal of Physics D: Applied Physics, 49(4), 2015, DOI: 10.1088/0022-3727/49/4/045007.
     
  • v. Gladiß, A., Graeser, M., Lüdtke-Buzug, K. and Buzug, T. M.: Contribution of brownian rotation and particle assembly polarisation to the particle response in magnetic particle spectrometry, Current Directions in Biomedical Engineering, 1(1), 298-301, 2015, DOI: 10.1515/cdbme-2015-0074.
     
  • Graeser, M., Bente, K. and Buzug, T. M.: Dynamic Single-Domain Particle Model for Magnetite Particles with Combined Crystalline and Shape Anisotropy, Journal of Physics D: Applied Physics, 48(27), 275001, 2015, DOI: 10.1088/0022-3727/48/27/275001.
     
  • Panagiotopoulos, N., Duschka, R. L., Ahlborg, M., Bringout, G., Debbeler, C., Graeser, M., Kaethner, C., Lüdtke-Buzug, K., Medimagh, H., Stelzner, J., Buzug, T. M., Barkhausen, J., Vogt, F. and Haegele, J.: Magnetic particle imaging: current developments and future directions, International Journal of Nanomedicine, 10, 3097-3114, 2015, DOI: 10.2147/ijn.s70488.
     
  • Graeser, M., Ahlborg, M., Behrends, A., Bente, K., Bringout, G., Debbeler, C., v. Gladiß, A., Gräfe, K., Kaethner, C., Kaufmann, S., Lüdtke-Buzug, K., Medimagh, H., Stelzner, J., Weber, M. and Buzug, T. M.: A Device for Measureing the Trajectorey Dependent Magnetic Particle Performance for MPI, In: International Workshop on Magnetic Particle Imaging, 2015, DOI: 10.1109/IWMPI.2015.7107078.
     

2014 [ to top ]

  • Haegele, J., Lüdtke-Buzug, K., Schaecke, C., Graeser, M., Duschka, R. L., Panagiotopoulos, N., Buzug, T. M., Vogt, F. and Barkhausen, J.: Magnetic particle imaging: kinetics of the intravascular signal in vivo, International Journal of Nanomedicine, 4203-4209, 2014, DOI: 10.2147/ijn.s49976.
     

2013 [ to top ]

  • Graeser, M., Knopp, T., Grüttner, M., Sattel, T. F., Bringout, G., Tenner, W., Wojtczyk, H. and Buzug, T. M.: Cancellation techniques for MPI, In: International Workshop on Magnetic Particle Imaging, 2013, DOI: 10.1109/IWMPI.2013.6528331.
     
  • Graeser, M., Knopp, T., Grüttner, M., Sattel, T. F. and Buzug, T. M.: Analog receive signal processing for magnetic particle imaging, Medical Physics, 40(4), 042303, 2013, DOI: 10.1118/1.4794482.
     
  • L, A. and K, L. -B.: Investigation of Different Tissue Samples with ΜCT and MPS for Determination of Iron Oxide Concentration in Tracers for MPI, In: Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 2013, DOI: 10.1515/bmt-2013-4100.
     

2012 [ to top ]

  • Graeser, M., Knopp, T., Sattel, T. F., Grüttner, M. and Buzug, T. M.: Signal separation in magnetic particle imaging, In: Nuclear Science Symposium and Medical Imaging Conference, 2483-2485, 2012, DOI: 10.1109/NSSMIC.2012.6551566.
     
  • Graeser, M., Biederer, S., Grüttner, M., Wojtczyk, H., Sattel, T. F., Tenner, W., Bringout, G. and Buzug, T. M.: Determination of System Functions for Magnetic Particle Imaging, In: Springer Proceedings in Physics, 59-64, 2012, DOI: 10.1007/978-3-642-24133-8_10.
     
  • Marquina-Sanchez, R., Kaufmann, S., Ryschka, M., Sattel, T. F. and Buzug, T. M.: A Control Unit for a Magnetic Particle Spectrometer, In: Springer Proceedings in Physics, 309-312, 2012, DOI: 10.1007/978-3-642-24133-8_49.
     

2011 [ to top ]

  • Graeser, M., Biederer, S., Grüttner, M., Wojtczyk, H., Tenner, W., Sattel, T. F., Gleich, B., Borgert, J. and Buzug, T. M.: Determination of a 1D-MPI-System-Function using a Magnetic Particle Spectroscope, In: Biomed Tech, 2011.
     

2010 [ to top ]

  • Vogt, F. M., Barkhausen, J., Biederer, S., Sattel, T. F., Knopp, T., Lüdtke-Buzug, K. and Buzug, T. M.: Current Iron Oxide Nanoparticles - Impact on MRI and MPI, In: International Workshop on Magnetic Particle Imaging, 12, 2010.
     
  • Biederer, S., Sattel, T. F., Knopp, T., Erbe, M., Lüdtke-Buzug, K., Vogt, F. M., Barkhausen, J. and Buzug, T. M.: A Spectrometer to Measure the Usability of Nanoparticles for Magnetic Particle Imaging, In: Magnetic Nanoparticles: Particle Science, Imaging Technology, and Clinical Applications, 60-65, 2010.
     
  • Biederer, S., Knopp, T., Sattel, T. F., Erbe, M. and Buzug, T. M.: Improved Estimation of the Magnetic Nanoparticle Diameter with a Magnetic Particle Spectrometer and Combined Fields, In: International Society for Magnetic Resonance in Medicine, 954, 2010.
     

2009 [ to top ]

  • Biederer, S., Knopp, T., Sattel, T. F., Lüdtke-Buzug, K., Gleich, B., Weizenecker, J., Borgert, J. and Buzug, T. M.: Estimation of Magnetic Nanoparticle Diameter with a Magnetic Particle Spectrometer, In: World Congress on Medical Physics and Biomedical Engineering, 61-64, 2009, DOI: 10.1007/978-3-642-03887-7_17.
     
  • Biederer, S., Sattel, T. F., Knopp, T., Lüdtke-Buzug, K., Gleich, B., Weizenecker, J., Borgert, J. and Buzug, T. M.: The Influence of the Particle-Size Distribution on the Image Resolution in Magnetic Particle Imaging, In: Magnetic Resonance Materials in Physics, Biology and Medicine, 499, 2009.
     
  • Biederer, S., Vogt, F. M., Lüdtke-Buzug, K., Knopp, T., Sattel, T. F., Barkhausen, J. and Buzug, T. M.: A Study on the Performance of Different Superparamagnetic Iron Oxide Particles in Magnetic Particle Imaging, In: Magnetic Resonance Materials in Physics, Biology and Medicine, 709, 2009.
     
  • Biederer, S., Knopp, T., Sattel, T. F., Lüdtke-Buzug, K., Gleich, B., Weizenecker, J., Borgert, J. and Buzug, T. M.: Magnetization response spectroscopy of superparamagnetic nanoparticles for magnetic particle imaging, Journal of Physics D: Applied Physics, 42(20), 205007, 2009, DOI: 10.1088/0022-3727/42/20/205007.