Single Sided Magnetic Particle Imaging

Most of the published MPI scanner use a setup, where the field of view lies in between a symmetric coil configuration. This, however, poses a size limitation for the specimens. In this project, we present a feasibility study of a new, so-called single-sided scanner, which is applied to the object of interest merely from one side. Thus, the problem of the specimen fitting into the scanner no longer exists, which denotes a major step for MPI. To date, the FOV of the Single Sided device is limited to two dimensions. First one dimension experimental results on imaging phantoms containing a super paramagnetic fluid show a resolution of up to 1 mm and are indeed promising.

The Single Sided setup for 2D imaging consists of two concentric circular coils and on D-shaped coil pair and is constructed at the Institute. One of its medical application scenarios is the detection of the sentinel lymph node. Super-paramagnetic iron oxide nanoparticles (SPIONs) are used as tracer material and will be injected into the breast tumour. Via the lymphatic system, the SPIONs reach the sentinel lymph node, which will be detected and accurately located with the Single Sided MPI scanner.

Single Sided MPI Scanner at the Institute of Medical Engineering.

Grants

  • Federal Ministry of Education and Research under grant number BMBF 01EZ0912.

Cooperations

  • Department of Gynecology and Obstetrics

Publications

[ 2018 ] [ 2016 ] [ 2015 ] [ 2014 ] [ 2013 ] [ 2012 ] [ 2010 ] [ 2009 ]

2018 [ to top ]

  • Gräfe, K., von Gladiss, A. and Buzug, T. M.: First Phantom Measurements with a 3D Single Sided MPI Scanner, In: International Workshop on Magnetic Particle Imaging, 2018.
     

2016 [ to top ]

  • Weissert, P., von Gladiss, A. and Buzug, T. M.: Comparing Different Compressed Sensing Reconstruction Techniques for the System Matrix in Single-Sided MPI, In: Student Conference Medical Engineering Science, 225-228, 2016.
     
  • Bringout, G., Gräfe, K. and Buzug, T. M.: MPI System Matrix Reconstruction: Making Assumptions on the Imaging Device rather than on the Tracer Spatial Distribution, In: International Workshop on Magnetic Particle Imaging, 174, 2016.
     
  • Gräfe, K., von Gladiss, A., Ahlborg, M., Bringout, G. and Buzug, T. M.: Reconstruction of a 2D Phantom Recorded with a Single-Sided MPI Device, In: International Workshop on Magnetic Particle Imaging, 23, 2016.
     
  • Blancke Soares, Y., von Gladiss, A., Ahlborg, M., Gräfe, K. and Buzug, T. M.: Comparison of Frequency Selection Methods for Image Reconstruction in Magnetic Particle Imaging - Improving Image Quality -, In: Student Conference Medical Engineering Science, 221-224, 2016.
     
  • Gräfe, K., von Gladiß, A., Bringout, G., Ahlborg, M. and Buzug, T. M.: 2D Images Recorded With a Single-Sided Magnetic Particle Imaging Scanner, IEEE Transactions on Medical Imaging, 35(4), 1056-1065, 2016, DOI: 10.1109/TMI.2015.2507187.
     

2015 [ to top ]

  • Finas, D., Stegemann-Frehse, J., Sauer, B., Hüttmann, G., Gräfe, K., Rody, A., Buzug, T. M. and Lüdtke-Buzug, K.: SPIO processing in macrophages for MPI - the breast cancer MPI-SNLB-concept, In: Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 228, 2015, DOI: 10.1515/bmt-2015-5010.
     
  • v. Gladiß, A., Gräfe, K., Ahlborg, M. and Buzug, T. M.: Undersampling the system matrix of a single sided MPI-scanner, In: International Workshop on Magnetic Particle Imaging, 2015, DOI: 10.1109/IWMPI.2015.7107021.
     
  • Gräfe, K., v. Gladiß, A., Bringout, G., Ahlborg, M. and Buzug, T. M.: 2D Imaging with a Single-Sided MPI Device, In: International Workshop on Magnetic Particle Imaging, 2015, DOI: 10.1109/IWMPI.2015.7107024.
     
  • Gräfe, K., Bringout, G., Graeser, M., Sattel, T. F. and Buzug, T. M.: System Matrix Recording and Phantom Measurements with a Single-Sided Magnetic Particle Imaging Device, IEEE Transactions on Magnetics, 51(2), 6502303, 2015, DOI: 10.1109/TMAG.2014.2330371.
     
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Rody, A., Gräfe, K., Buzug, T. M. and Lüdtke-Buzug, K.: SPIO Detection and Distribution in Biological Tissue - A Murine MPI-SLNB Breast Cancer Model, IEEE Transactions on Magnetics, 51(2), 5400104, 2015, DOI: 10.1109/TMAG.2014.2358272.
     

2014 [ to top ]

  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Rody, A., Gräfe, K., Buzug, T. M. and Lüdtke-Buzug, K.: SPIO detection and distribution in biological tissue – a murine MPI-SNLB breast cancer model, In: International Workshop on Magnetic Particle Imaging, 166, 2014.
     
  • Gräfe, K., Bringout, G., Graeser, M., Sattel, T. F. and Buzug, T. M.: System Matrix Recording and Phantom Measurements with a Single-Sided Magnetic Particle Imaging Device, In: International Workshop on Magnetic Particle Imaging, 92, 2014.
     
  • Baumann, K., Stegmann-Frehse, J., Rody, A., Gräfe, K., Lüdtke-Buzug, K., Buzug, T. and Finas, D.: Weiterentwicklung des SNLB-Konzept unter Verwendung von SPIOs beim Mammakarzinom - Prozessierung der Nanopartikel im Organismus, Senologie, 11-A13, 2014, DOI: 10.1055/s-0034-1375372.
     
  • Finas, D., Baumann, K., Stegemann-Frehse, J., Gräfe, K., Rody, A., Buzug, T. M. and Lüdtke-Buzug, K.: Processing of nanoparticles in organism - further development of the breast cancer SNLB-concept using SPIOs and MPI, In: Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 314, 2014, DOI: 10.1515/bmt-2014-5003.
     

2013 [ to top ]

  • Gräfe, K., Weber, M., Sattel, T. F. and Buzug, T. M.: Precision of an MPI Scanner Construction: Registration of Measured and Simulated Magnetic Fields, In: Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 2013, DOI: 10.1515/bmt-2013-4258.
     
  • Mrongowius, J., Gräfe, K. and Buzug, T. M.: Simulation Study of a Single-Sided Magnetic Particle Imaging Device, In: Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 2013, DOI: 10.1515/bmt-2013-4285.
     
  • Gräfe, K., Grüttner, M., Sattel, T. F., Graeser, M. and Buzug, T. M.: Single-sided magnetic particle imaging: magnetic field and gradient, In: SPIE Medical Imaging, 867219, 2013, DOI: 10.1117/12.2001610.
     
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Rody, A., Lüdtke-Buzug, K. and Buzug, T. M.: Superparamagnetic nanoparticles in lymphatic tissue - Detection and distribution in a breast cancer model for magnetic particle imaging, In: International Workshop on Magnetic Particle Imaging, 2013, DOI: 10.1109/IWMPI.2013.6528390.
     
  • Gräfe, K., Grüttner, M., Sattel, T. F., Kaethner, C. and Buzug, T. M.: Phantom simulation based on measured gradient fields of a single-sided MPI scanner, In: International Workshop on Magnetic Particle Imaging, 2013, DOI: 10.1109/IWMPI.2013.6528352.
     

2012 [ to top ]

  • Gräfe, K., Sattel, T. F., Lüdtke-Buzug, K., Finas, D., Borgert, J. and Buzug, T. M.: Magnetic-Particle-Imaging for Sentinel Lymph Node Biopsy in Breast Cancer, In: Springer Proceedings in Physics, 237-241, 2012, DOI: 10.1007/978-3-642-24133-8_38.
     
  • Finas, D., Baumann, K., Heinrich, K., Ruhland, B., Sydow, L., Gräfe, K., Sattel, T. F., Lüdtke-Buzug, K. and Buzug, T. M.: Distribution of Superparamagnetic Nanoparticles in Lymphatic Tissue for Sentinel Lymph Node Detection in Breast Cancer by Magnetic Particle Imaging, In: Springer Proceedings in Physics, 187-191, 2012, DOI: 10.1007/978-3-642-24133-8_30.
     
  • Gräfe, K., Sattel, T. F., Lüdtke-Buzug, K., Finas, D., Borgert, J. and Buzug, T. M.: An Application Scenario for Single-Sided Magnetic Particle Imaging, In: Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 514, 2012, DOI: 10.1515/bmt-2012-4343.
     
  • Finas, D., Baumann, K., Sydow, L., Heinrich, K., Gräfe, K., Buzug, T. M. and Lüdtke-Buzug, K.: Detection and distribution of superparamagnetic nanoparticles in lymphatic tissue in a breast cancer model for magnetic particle imaging, In: Deutsche Gesellschaft für Biomedizinische Technik Jahrestagung, 81-83, 2012, DOI: 10.1515/bmt-2012-4158.
     

2010 [ to top ]

  • Sattel, T. F., Knopp, T., Biederer, S., Erbe, M., Lüdtke-Buzug, K. and Buzug, T. M.: Resolution Distribution in Single-Sided Magnetic Particle Imaging, In: Magnetic Nanoparticles: Particle Science, Imaging Technology, and Clinical Applications, 106-112, 2010, DOI: 10.1142/9789814324687_0015.
     
  • Finas, D., Ruhland, B., Baumann, K., Knopp, T., Sattel, T. F., Biederer, S., Lüdtke-Buzug, K., Buzug, T. M. and Diedrich, K.: Sentinal Lymphnode Detection in Breast Cancer by Magnetic Particle Imaging Using Superparamagnetic Nanoparticles, In: International Workshop on Magnetic Particle Imaging, 35, 2010, DOI: 10.1142/9789814324687_0029.
     
  • Sattel, T. F., Biederer, S., Knopp, T. and Buzug, T. M.: Magnetic Field Generation For Multi-Dimensional Single-Sided Magnetic Particle Imaging, In: International Society for Magnetic Resonance in Medicine, 3297, 2010.
     

2009 [ to top ]

  • Sattel, T. F., Knopp, T., Biederer, S., Gleich, B., Weizenecker, J., Borgert, J. and Buzug, T. M.: Single-Sided Device for Magnetic Particle Imaging, Journal of Physics D: Applied Physics, 42(2), 022001, 2009.
     
  • Sattel, T. F., Biederer, S., Knopp, T., Lüdtke-Buzug, K., Gleich, B., Weizenecker, J., Borgert, J. and Buzug, T. M.: Single-Sided Coil Configuration for Magnetic Particle Imaging, In: World Congress on Medical Physics and Biomedical Engineering, 281-284, 2009, DOI: 10.1007/978-3-642-03885-3_78.
     
  • Sattel, T. F., Biederer, S., Knopp, T., Lüdtke-Buzug, K., Gleich, B., Borgert, J. and Buzug, T. M.: Hand-Held Concept of a Magnetic Particle Imaging Device, In: Molecular Imaging and Biology, J521, 2009.